Tripartite Motif Containing Protein 42 (TRIM42)

TRIM42 encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses. TRIM proteins are involved in pathogen-recognition and by regulation of transcriptional pathways in host defence.The tripartite motif is always present at the N-terminus of the TRIM proteins. The TRIM motif includes the following three domains:(1) a RING finger domain(2) one or two B-box zinc finger domains(3) coiled coil region.