Tripartite Motif Containing Protein 69 (TRIM69)

RNF36; Trif; HSD34; TRIMLESS; Ring Finger Protein 36; RFP-like domain-containing protein trimless; E3 ubiquitin-protein ligase TRIM69

Tripartite Motif Containing Protein 69 (TRIM69)
TRIM69encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. TRIM69 is a 500 amino acid protein that belongs to the TRIM family and contains one RINGtype zinc finger and one B30.2/SPRY domain. Localizing to nuclear speckles, TRIM69 interacts with PML (promyelocytic leukemia) and is thought to play a role in spermatogenesis and, when overexpressed, may be involved in apoptosis. TRIM69 is subject to posttranslational phosphorylation, an event which is necessary for TRIM69 nuclear localization. Multiple isoforms of TRIM69 exist due to alternative splicing events.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)