Tripeptidyl Peptidase I (TPP1)

CLN2; GIG1; LPIC; Tripeptidyl aminopeptidase; Lysosomal pepstatin-insensitive protease; Ceroid-Lipofuscinosis,Neuronal 2,Late Infantile; Cell growth-inhibiting gene 1 protein
Tripeptidyl Peptidase I (TPP1)
Tripeptidyl-peptidase 1 is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity.
It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPC828Ra01Recombinant Tripeptidyl Peptidase I (TPP1)Customize
  • AntibodyPAC828Ra01Polyclonal Antibody to Tripeptidyl Peptidase I (TPP1)Customize
  • AntibodyMAC828Ra21Monoclonal Antibody to Tripeptidyl Peptidase I (TPP1)Customize
  • Assay KitSEC828RaELISA Kit for Tripeptidyl Peptidase I (TPP1)Customize
  • Assay KitSCC828RaCLIA Kit for Tripeptidyl Peptidase I (TPP1)Customize
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