Tripeptidyl Peptidase I (TPP1)
CLN2; GIG1; LPIC; TPP I; Ceroid-Lipofuscinosis,Neuronal 2,Late Infantile(Jansky-Bielschowsky Disease)
is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity.
It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
||Recombinant Tripeptidyl Peptidase I (TPP1)
||Polyclonal Antibody to Tripeptidyl Peptidase I (TPP1)
||Monoclonal Antibody to Tripeptidyl Peptidase I (TPP1)
||ELISA Kit for Tripeptidyl Peptidase I (TPP1)
||CLIA Kit for Tripeptidyl Peptidase I (TPP1)