Tubulin Beta 1 (TUBb1)

Microtubules are involved in a wide variety of cellular processes, including mitosis, morphogenesis, platelet formation, and mobility of cilia and flagella. Circulating platelets carry a single marginal microtubule coil that is wound in 8 to 12 turns and is responsible for platelet shape. TUBB1 is the major beta-tubulin expressed in platelets and megakaryocytes and is required for optimal platelet assembly

Northern blot analysis of several adult mouse tissues detected highest Tubb1 expression in spleen, with much lower expression in lung. Weak expression was detected in spleen, liver, and lung of young mice.the C terminus of mouse Tubb1 interacted with the protease inhibitor Slpi.