Tubulin Polymerization Promoting Protein 3 (TPPP3)

Microtubules (MTs) play an important role in cell division, and their functions are regulated by a set of microtubule-associated proteins (MAPs).

Tubulin polymerization promoting protein family member 3 (TPPP3), also known as p20, is a new member of the tubulin polymerization promoting protein (TPPP) family. TPPP3 specifically binds to MTs and positively regulates MTs assembly, which leads to significant ultrastructural alterations of the MTs network.

However, the physiological function of TPPP3 is still largely unknown. TPPP3 played a crucial role in cell mitosis by regulating centrosomes amplification and/or spindles translocation processes.