Tumor Protein p53 Binding Protein 1 (TP53BP1)
53BP1; p53BP1; p202
TP53BP1 has a predicted molecular mass of 217 kD and shows homology in its C-terminal 247 amino acids to the C terminus of the tumor suppressor protein BRCA1. TP53BP1 was present in both the cytoplasm and nucleus in some cells and only in the nucleus in others. Furthermore, there were 2 nuclear staining patterns, one homogeneous staining and the other dot staining.TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation. TP53BP1 played a partially redundant role in phosphorylation of the downstream checkpoint effector proteins BRCA1 and CHK2 but was required for the formation of BRCA1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
Organism species: Homo sapiens (Human)
- Recombinant protein RPH009Hu01 Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) In Stock
- Modified protein MPH009Hu01 Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) In Stock
- Monoclonal antibody MAH009Hu21 Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) In Stock
- Polyclonal antibody PAH009Hu01 Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) In Stock
- Anti-Modified antibody AAH009Hu01 Anti-Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody In Stock
- Anti-Modified antibody AAH009Hu02 Anti-Phosphorylated Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody In Stock
- Sandwich ELISA SEH009Hu ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) In Stock
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Tumor Protein p53 Binding Protein 1 (TP53BP1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Tumor Protein p53 Binding Protein 1 (TP53BP1) ELISA Kit Customized Service Offer