U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1)
RN; RNU2AF1; U2AF35; U2AFBP; U2 auxiliary factor 35 kDa subunit; U2 snRNP auxiliary factor small subunit
U2AF1 belongs to the splicing factor SR family of genes.This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.DEK phosphorylated at serines 19 and 32 associates with U2AF35, facilitates the U2AF35-AG interaction, and prevents binding of U2AF65 to pyrimidine tracts not followed by AG. DEK and its phosphorylation are required for intron removal, but not for splicing complex assembly, which indicates that proofreading of early 3-prime splice site recognition influences catalytic activation of the spliceosome.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) ELISA Kit Customized Service Offer