U3 Small Nucleolar Ribonucleoprotein 18, Homolog (UTP18)

Yeast Upt18 is a component of a ribonucleoprotein required for biogenesis of the 18S rRNA.UTP18/WDR50 is a component of the small-subunit (SSU) processome, a large ribonucleoprotein complex that participates in ribosomal RNA processing and ribosome assembly. UTP18/WDR50 is a member of the WD repeat family. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. Alternate names for UTP18/WDR50 include U3 small nucleolar RNA-associated protein 18 homolog, WD repeat-containing protein 50, and CG1-48.