UBX Domain Protein 6 (UBXN6)

By database analysis, Carim-Todd et al. (2001) identified UBXD1. They isolated 2 transcripts encoding predicting proteins of 388 and 441 amino acids with calculated molecular masses of 43.8 and 49.7 kD, respectively. UBXD1 contains a C-terminal UBX domain, characteristic of ubiquitin regulatory proteins, and shares 80% and 79% amino acid identity with the mouse and rat homologs, respectively. Northern blot analysis of adult human tissues detected 1.6-, 1.8-, and 5.5-kb transcripts with highest expression in testis, followed by prostate, spleen, thymus, small intestine, colon, blood leukocytes, and uterus.UBXD1 gene contains 11 exons with an alternatively spliced exon 1a. The 1.8-kb transcript contains an in-frame stop codon in exon 1a preceding a second open reading frame and results in the shorter isoform.