UDP Glucuronosyltransferase 2 Family, Polypeptide B10 (UGT2B10)

The UGTs (EC 2.4.1.17) are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. By screening a liver library with a rat UGT2B1 cDNA, Jin et al. (1993) isolated cDNAs encoding UGT2B4, which they called UGT2B11, and UGT2B10.

The predicted 528-amino acid UGT2B10 protein contained an N-terminal signal peptide and a C-terminal transmembrane hydrophobic region. Mammalian cells expressing UGT2B10 produced a 49-kD protein that was recognized by a UGT-specific polyclonal antibody. However, the expressed protein exhibited no glucuronidation activity towards more than 40 xenobiotics and steroids tested.