Polypeptide-N-Acetylgalactosaminyltransferase 14 (GALNT14)

GALNT14 (EC 2.4.1.41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates.

The deduced 552-amino acid type II membrane protein has an N-terminal cytoplasmic domain, followed by a transmembrane domain, a stem region, and a catalytic domain. The catalytic domain contains a GT1 motif, a Gal/GalNAc transferase motif, and a ricin-like lectin motif, which is commonly found in GALNT proteins. GALNT14 shares 49.9% amino acid homology with GALNT2.