Ubiquinol Cytochrome C Reductase Complex Chaperone (UQCC)
C20orf44; CBP3; BFZB; Basic FGF-Repressed Zic-Binding Protein; Ubiquinol-cytochrome-c reductase complex assembly factor 1
Uqcc, called Bfzb, and identified its human homolog by database analysis. The deduced human and mouse proteins have a single transmembrane domain and share 94% amino acid identity. In situ hybridization of mouse embryos detected Bfzb predominantly in the developing nervous system, with highest expression in proliferating neuroepithelia of brain and neural tube, ganglia of cranial nerves V, VII, VIII, IX, and X, and dorsal root ganglia.
Transcripts were also detected in developing eye and brown fat. In adult mouse brain, strong expression was restricted to olfactory bulb, hippocampus, and piriform cortex and Purkinje cells of cerebellum. The Bfzb protein localized to cytoplasmic vesicular structures.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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