Ubiquitin Associated Domain Containing Protein 1 (UBAC1)

The deduced 404-amino acid protein has a calculated molecular mass of about 44.4 kD. GBDR1 contains a C-terminal helix-loop-helix motif and an SRC homology-3 (SH3) domain. It has several putative phosphorylation sites, including 8 CK2 sites, as well as 1 N-glycosylation site and 2 N-myristoylation sites. The 5-prime untranslated region of the transcript contains a CpG island, and the 3-prime region contains 2 mRNA instability motifs.

Cell fractionation revealed GBDR1 in the membrane fraction, and detergent treatment indicated that GBDR1 associates with nuclear membranes. In HMVECs, GBDR1 showed a punctate cytoplasmic distribution and a variable number of nuclear