Ubiquitin Conjugating Enzyme E2R2 (UBE2R2)

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.

UBC3B is highly homologous to UBC3 (CDC34), with only 47 amino acid differences, and has the conserved cysteine and leucine residues that are part of the active site in ubiquitin-conjugating enzymes (E2). The UBC3B protein shares 35% sequence identity with S. cerevisiae cdc34.