Ubiquitin Domain Containing Protein 1 (UBTD1)

UBTD1 contains a ubiquitin domain, and has been demonstrated to bind to p53 in cells. p53 is linked to the ubiquitination pathway through its transcriptional regulation of the four ubiquitin ligases, MDM2, COP1, Siah1b, and Pirh2. The role of UBTD1 has not been elucidated, however preliminary evidence indicates a potential role in p53 signaling.

UBTD1 is well expressed, 1.2 times the average gene in this release. UBTD1 contains 2 different gt-ag introns.The spliced mRNA putatively encodes a good protein, containing Ubiquitin domain, a N-myristoylation domain. Transcription produces one mRNA.UBTD1 has been proposed to participate in a process (protein modification). Proteins are expected to localize in nucleus. A putative protein interactor has been described (TRIM39). UBTD1 maps on chromosome 10, at 10q24.1.