Ubiquitin Like Domain Containing CTD Phosphatase 1 (UBLCP1)

UBLCP1 encodes a 318-amino acid protein with a predicted molecular mass of 36.8 kD. It has a CTD phosphatase catalytic domain containing several residues essential for catalytic activity that are conserved with those in the CTD phosphatases CTDSP1 and CTDP1.

UBLCP1 also contains an N-terminal ubiquitin-like domain that harbors a proteasome-interacting motif. RT-PCR detected relatively high expression of UBLCP1 in placenta, lung, testis, and ovary, with weaker expression in heart, liver, kidney, spleen, thymus, colon, and peripheral blood leukocytes. UBLCP1 expression was particularly high in breast, lung, colon, prostate, ovarian, and pancreas tumor tissues. Immunofluorescence analysis localized UBLCP1 to the nucleus.