Ubiquitin Like Protein 4A (UBL4A)

Martini et al. (1986) reported on the isolation and analysis of human genomic DNA clones spanning about 100 kb of the X chromosome and containing the 18-kb long glucose-6-phosphate dehydrogenase gene. About 40 kb downstream of G6PD, they found another ubiquitously transcribed region they provisionally named the GDX gene. It is transcribed in the same direction as the G6PD gene. Several overlapping lambda and cosmid clones linked them to the G6PD gene. Both lie about 40 kb downstream from the G6PD gene. Protein P3 and protein GDX are contained within 7 kb of DNA. The 3-prime end of the P3 gene is 0.5 kb upstream from the GDX gene. P3 and GDX show no sequence homology between themselves or G6PD or to any previously described genes, but they appear to have been conserved in evolution.