Ubiquitin Protein Ligase E3 Component N-Recognin 3 (UBR3)

UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. The similarities of UBR3 to the UBR1 and UBR2 E3s of the N-end rule pathway include the RING and UBR domains.

The adult UBR3 mice had female-specific behavioral anosmia. Cells of the olfactory pathway were found to express beta-galactosidase (LacZ) that marked the deletion/disruption UBR3- allele. The UBR3-specific LacZ expression was also prominent in cells of the touch, vision, hearing, and taste systems, suggesting a regulatory role of UBR3 in sensory pathways, including olfaction. UBR box of UBR3 may recognize small compounds that modulate the targeting, by this E3, of its currently unknown substrates.