Ubiquitin Protein Ligase E3 Component N-Recognin 7 (UBR7)

UBR7 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

Ubiquitin chain assembly can also be blocked by overover,expression of UbR7. However, UbR7’s effects have not been characterized extensivley, and it has not been ruled out that UbR7 does not influence ubiquitin-inde-pendent turnover. Even if a labile protein is stabilized upon inhibiting multiubiquitination in trans, it is difficult to exclude that the target is stabilized indirectly by activation/accumulation of an inhibitor of its destruction.