Ubiquitin Specific Peptidase 35 (USP35)

Ubiquitin specific peptidase 35 (USP35) is a thioesterase enzyme that catalyzes the hydrolysis of ubiquitin from ubiquitin conjugates. USP35 belongs to the peptidase C19 family.

Ubiquitin-specific proteases help to regulate many cellular processes by controlling the amount of the protein ubiquitin. Ubiquitin is an essential part of a multi-step process called the ubiquitin-proteasome system, which helps control the levels of many proteins in the cell. Attaching ubiquitin to another protein serves to target that protein for destruction by the proteasome. Mutations that affect the function of ubiquitin-specific proteases are associated with a number of cancers as well as other disorders involving inflammation and the regulation of cell death.