Ubiquitin Specific Peptidase 36 (USP36)

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes. The deduced protein contains 1,123 amino acids. RT-PCR ELISA detected highest expression in testis and ovary, with weaker expression in all other adult and fetal tissues and specific brain regions examined.The deduced protein contains cysteine, histidine, and asparagine residues required for catalytic activity, and it has a QQD box characteristic of USPs. Northern blot analysis detected a major USP36 transcript highly expressed in skeletal muscle and testis. Variable expression was detected in other tissues examined.