Unconventional SNARE In The ER 1 (USE1)
SLT1; p31; Q-SNARE; SNARE-Like Tail-Anchored Protein 1 Homolog; Vesicle transport protein USE1; Putative MAPK-activating protein PM26; USE1-like protein
D12 is a SNARE protein that binds to syntaxin-18, Sec22b, alpha-SNAP, and VAMP7, thus showing that D12 interacts with SNARES involved in the early and the post-Golgi secretory apparatus and with endosome-lysosome transport. Immunofluorescence and siRNA assays showed that neither overexpression nor knockdown of D12 affected ER, Golgi, or ER-Golgi intermediate compartment structures, suggesting that D12 does not regulate membrane trafficking in the early secretory pathway. However, D12 knockdown did induce apoptosis, as measured by condensed nuclear chromatin, caspase-3 activation, and BAX conformational change. In addition, D12 downregulation caused rapid appearance of lipofuscin granules, suggesting impaired degradation of mitochondria by lysosomal degradative enzymes.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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