Unkempt Homolog Like Protien (UNKL)

UNKL May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.Belongs to the unkempt family.

Contains 4 C3H1-type zinc fingers.Contains 1 RING-type zinc finger. Isoform 4 (C-terminal) interacts with the GTP-bound form of RAC1. Isoform 4 (C-terminal) interacts with SMARCD2/BAF60b.Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven. Isoform 4 is ubiquitinated in the C-terminal. Ubiquitination is enhanced by activated RAC1. The presence of the RING finger domain is not essential for ubiquitination to occur.