V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (ABL2)

The detection of a novel 12-kb transcript from this gene in human normal and tumor cells established it as a new member of the tyrosine kinase family that is closely related to but distinct from ABL. Kruh et al. (1990) assembled a full-length ARG cDNA by using the partial ARG sequence as probe to screen cDNA libraries prepared from K562, M426, and A172 cells and monocytes. The deduced 1,182-amino acid ARG protein shows high similarity to ABL in overall structural architecture as well as in the sequence of the tyrosine kinase domain and the SH2 and SH3 domains. ARG, like ABL, is expressed as 2 transcripts that result from alternative splicing and encode alternative protein forms that differ only in their N termini and one of which contains a myristoylation site.