V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)

c-MAF; Proto-oncogene c-Maf; Transcription factor Maf

V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)
MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor.
This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.Members of the MAF family appear to play important roles in the regulation of differentiation.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)