V-Myb Myeloblastosis Viral Oncogene Homolog Like Protein 2 (MYBL2)

The MYBL2 gene belongs to the MYB family of transcription factor genes and plays an essential role during cell cycle progression. MYBL2 transcripts are detectable in a wide variety of dividing cell types. MYBL2 activates CDC2 and cyclin D1 gene expression in proliferating fibroblasts, and antisense oligonucleotides specific to MYBL2 inhibit proliferation of human hematopoietic cell lines.

MYBL2 expression is also regulated at the G1/S phase transition, and its transcription relies on E2F activity in a cell cycle-dependent manner. Thus, unlike MYB and MYBL1, whose transcriptional activity is mainly restricted to hematopoietic, spermatogenic, and neural progenitor cells, MYBL2 appears to possess a broader function during cell proliferation.