Transcription Factor P65 (NFKB3)
Nuclear factor NF-kappa-B p65 subunit; NFKBP65; RELA; p65; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3
The transcriptional coactivator CBP/p300 associates with through 2 sites, an N-terminal domain that interacts with the C-terminal region of unphosphorylated p65, and a second domain that only interacts with p65 phosphorylated on serine-276. Phosphorylation by PKA both weakens the interaction between the N- and C-terminal regions of p65 and creates an additional site for interaction with CBP/p300. Therefore, PKA regulates the transcriptional activity of NF-kappa-B by modulating its interaction with CBP/p300.
The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB ), which inactivate NFKB by trapping it in the cytoplasm.
Organism species: Homo sapiens (Human)
- Recombinant protein RPA616Hu01 Recombinant Transcription Factor P65 (NFKB3) In Stock
- Polyclonal antibody PAA616Hu01 Polyclonal Antibody to Transcription Factor P65 (NFKB3) In Stock
- Monoclonal antibody MAA616Hu22 Monoclonal Antibody to Transcription Factor P65 (NFKB3) In Stock
- Sandwich ELISA SEA616Hu ELISA Kit for Transcription Factor P65 (NFKB3) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPA616Mu01 Recombinant Transcription Factor P65 (NFKB3) In Stock
- Polyclonal antibody PAA616Mu01 Polyclonal Antibody to Transcription Factor P65 (NFKB3) In Stock
- Labelled antibody LAA616Mu71 Biotin-Linked Polyclonal Antibody to Transcription Factor P65 (NFKB3) In Stock
- Labelled antibody LAA616Mu81 FITC-Linked Polyclonal Antibody to Transcription Factor P65 (NFKB3) In Stock
- Customized Service n/a CLIA Kit for Transcription Factor P65 (NFKB3) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Transcription Factor P65 (NFKB3) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPA616Ra01 Recombinant Transcription Factor P65 (NFKB3) In Stock
- Polyclonal antibody PAA616Ra01 Polyclonal Antibody to Transcription Factor P65 (NFKB3) In Stock
- Monoclonal antibody MAA616Ra21 Monoclonal Antibody to Transcription Factor P65 (NFKB3) In Stock
- Sandwich ELISA SEA616Ra ELISA Kit for Transcription Factor P65 (NFKB3) In Stock
Organism species: Danio rerio (Zebrafish)
- Recombinant protein RPA616Fi01 Recombinant Transcription Factor P65 (NFKB3) In Stock
- Customized Service n/a Monoclonal Antibody to Transcription Factor P65 (NFKB3) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Transcription Factor P65 (NFKB3) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Transcription Factor P65 (NFKB3) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Transcription Factor P65 (NFKB3) ELISA Kit Customized Service Offer