V-Crk Sarcoma Virus CT10 Oncogene Homolog (CRK)

CRK is a gene which codes a protein exhibiting the SH2 domain.This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.