VEGF Co Regulated Chemokine 1 (VCC1)

CXCL17 is a small cytokine belonging to the CXC chemokine family that has been identified in humans and mice. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It is also known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC).

This chemokine is constitutively expressed in the lung.The predicted 119-amino acid protein has a calculated molecular mass of 13.8 kD and shares 71% identity with its mouse homolog. DMC has an N-terminal signal peptide, but no N-glycosylation sites. Secondary structure analysis showed highest similarity to CXCL8 (IL8), whereas circular dichroism analysis revealed that active, purified DMC adopted a secondary structure resembling that of CCL5  and CCL4.