Vav 2 Oncogene (VAV2)

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.Its overall exon organization is similar to that of VAV1. Alternative splicing of exons 6, 16, and 28 generates at least 2 distinct VAV2 mRNA species.

Moores et al. (2000) expressed VAV1, VAV2, and VAV3 at equivalent levels and found that each responds to similar surface receptor tyrosine kinases. Integrin-induced phosphorylation required the presence of SYK . Only VAV1 could efficiently cooperate with T-cell receptor (TCR) signaling to enhance NFAT-dependent transcription, while only VAV1 and VAV3 could enhance nuclear factor kappa-B (NFKB)-dependent transcription.