Vesicle Associated Membrane Protein 4 (VAMP4)

VAMP4 is a member of the vesicle-associated membrane protein family of trafficking proteins.VAMP4 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.

The predicted 141-amino acid protein contains an amphipathic helix that may participate in coiled-coil interactions and a C-terminal hydrophobic domain predicted to serve as a membrane anchor. Northern blot analysis detected transcripts of 1.4, 2.4, and 5.6 kb that are broadly expressed and abundant in heart. Transfection into normal rat kidney cells resulted in a punctate juxtanuclear staining pattern that partially overlaps with syntaxin-6 (STX6), a marker for the trans-Golgi network.