WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1)

The deduced 1,127-amino acid, 125-kD protein contains 7 WD repeats and a C-terminal HMG box. The HMG box is typical of some DNA-binding proteins involved in chromatin assembly, transcription, and replication. And1 also has several putative nuclear localization signals. And1 localized throughout the entire interchromatinic space of the interphase nucleoplasm, probably in homodimeric form. During mitosis, it was transiently dispersed over the cytoplasm. PCR of human cDNA libraries detected expression in brain, epidermis, liver, and stomach.By DNA affinity chromatography and electrophoretic mobility shift assays, Kohler et al. (1997) demonstrated that Xenopus And1 bound DNA.The International Radiation Hybrid Mapping Consortium mapped the AND1 gene to chromosome 14.