WD Repeat Containing Domain Protein 72 (WDR72)

WDR72 gene contains 19 exons and spans about 250 kb.The deduced 1,102-amino acid protein contains 7 WD40 domains, which are predicted to form the blades of a 7 beta propeller structure and function as a docking platform for protein-protein interactions.

WDR72 shares highest similarity with WDR7, which is involved in vesicle mobilization and Ca(2+)-dependent exocytosis at synapses. Database analysis suggested WDR72 is expressed in a wide variety of tissues. Immunohistochemical analysis of developing mouse incisors detected Wdr72 expression in the enamel organ, with more intense staining in maturation ameloblasts than in secretory ameloblasts. Wdr72 was also detected in some bone and connective tissue cells.