WD Repeat Containing Domain Protein 1 (WDR1)

WDR1 encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.

The deduced 606-amino acid human WDR1 protein shares 95% amino acid sequence identity with mouse Wdr1 and 86% identity with chicken Wdr1. Chicken Wdr1 has high sequence identity to S. cerevisiae and P. polycephalum WD repeat-containing proteins that bind actin, suggesting that WDR1 proteins may interact with actin.