WD Repeat Containing Domain Protein 5 (WDR5)

WDR5 encodes a member of the WD repeat protein family. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.The deduced 328-amino acid protein is composed primarily of 7 WD40 repeats in a beta-propeller structure. Northern blot analysis of several mouse tissues detected highest expression in testis. Wdr5 was also expressed in immortalized murine bone marrow stromal cells, osteoblasts, osteocytes, and growth plate chondrocytes, as well as in primary calvarial osteoblasts. Immunohistochemical analysis of embryonic mouse bone detected Wdr5 in osteoblasts of calvariae.