WD Repeat Containing Domain Protein 75 (WDR75)

WDR75 is a human protein encoded by the WDR75 gene containing a WD40 superfamily domain. The WD40 domain is found throughout many eukaryotic cell types and is known to be involved in cellular regulator functions such as pre-mRNA processing and cytoskeleton assembly. The function of the WDR75 protein is not defined by the scientific community. No helix-turn-helix (HTH) regions were predicted.No known paralogs exist for the Human gene. No paralogs were found for the cow, mouse, or rat orthologs of WDR75. Conservation among mammalian orthologs to the human gene was strong, with minimum identity amoug orthologs at 76%. The following table summarizes some vertebrate and invertebrate orthologs. Conservation of specific amino acids from positions 340-390, 430- 450, and 515-530 all correlate to predicted alpha helicies.