WNK Lysine Deficient Protein Kinase 4 (WNK4)

PHA2B; PRKWNK4; Protein Kinase,Lysine Deficient 4; Protein kinase with no lysine 4; Serine/threonine-protein kinase WNK4
WNK Lysine Deficient Protein Kinase 4 (WNK4)
WNK4 encodes a serine-threonine kinase expressed in distal nephron. Its primary role in renal physiolgy is as a molecular switch between the angiontensin II - aldosterone mediated volume retention and the aldosterone mediated potassium wasting. This is achieved by regulating the sodium-chloride symporter (NCC), that is uniquely expressed in the distal nephron and is sensitive to thiazide type diuretics. WNK4 will inhibit NCC function. It has been proposed that in the event of hyperkalemia and an increased secretion of aldosterone, this inhibition of NCC, will allow an increase in the arrival of sodium to the distal nephron which will allow the exchange of sodium for potassium ions, thereby reducing plasma potassium levels, without increasing sodium chloride retention.
Organism species: Homo sapiens (Human)
  • Protein RPG889Hu01Recombinant WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • AntibodyPAG889Hu01Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • AntibodyMAG889Hu21Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • Assay KitSEG889HuELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • Assay KitSCG889HuCLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPG889Mu01Recombinant WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • AntibodyPAG889Mu01Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • AntibodyMAG889Mu21Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • Assay KitSEG889MuELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • Assay KitSCG889MuCLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPG889Ra01Recombinant WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • AntibodyPAG889Ra01Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • AntibodyMAG889Ra21Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • Assay KitSEG889RaELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
  • Assay KitSCG889RaCLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4)Customize
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