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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
WNK Lysine Deficient Protein Kinase 4 (WNK4)
PHA2B; PRKWNK4; Protein Kinase,Lysine Deficient 4
WNK4 encodes a serine-threonine kinase expressed in distal nephron. Its primary role in renal physiolgy is as a molecular switch between the angiontensin II - aldosterone mediated volume retention and the aldosterone mediated potassium wasting. This is achieved by regulating the sodium-chloride symporter (NCC), that is uniquely expressed in the distal nephron and is sensitive to thiazide type diuretics. WNK4 will inhibit NCC function. It has been proposed that in the event of hyperkalemia and an increased secretion of aldosterone, this inhibition of NCC, will allow an increase in the arrival of sodium to the distal nephron which will allow the exchange of sodium for potassium ions, thereby reducing plasma potassium levels, without increasing sodium chloride retention.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPG889Hu01 Recombinant WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Antibodies PAG889Hu01 Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
MAG889Hu21 Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Assay Kits SEG889Hu ELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
SCG889Hu CLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPG889Mu01 Recombinant WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Antibodies PAG889Mu01 Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
MAG889Mu21 Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Assay Kits SEG889Mu ELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
SCG889Mu CLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPG889Ra01 Recombinant WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Antibodies PAG889Ra01 Polyclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
MAG889Ra21 Monoclonal Antibody to WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
Assay Kits SEG889Ra ELISA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize
SCG889Ra CLIA Kit for WNK Lysine Deficient Protein Kinase 4 (WNK4) Customize