Wings Apart Like Protein (WAPAL)

The WAPAL protein contains 1,287 amino acids. By Northern blot analysis, moderate expression was detected in placenta, lung, liver, thymus, prostate, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine, and peripheral blood leukocytes with weak expression in heart, brain, and colon.

WAPAL contains an N-terminal arginine-rich motif (ARM), a bipartite nuclear localization sequence, 3 highly acidic domains, 4 predicted coiled-coil domains, and a C-terminal nuclear export signal. WAPAL shares shares 38% amino acid identity over the C-terminal region with the parallel sister chromatid product (PASC) of the Drosophila wapl gene. Northern blot analysis detected 6.5- and 4.4-kb transcripts in all human tissues examined.