X Antigen Family, Member 3 (XAGE3)

PLAC6; GAGED4; XAGE-3; pp9012; CT12.3a; CT12.3b; Cancer/Testis Antigen Family 12,Member 3a; Placenta-Specific 6; G Antigen Family D 4

X Antigen Family, Member 3 (XAGE3)
XAGE3 is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR.
By homology walking using the dbEST database, Brinkmann et al. (1999) identified XAGE3, which was found in placenta and liver/spleen cDNA libraries. The deduced protein contains 111 amino acids.

Organism species: Homo sapiens (Human)