X-Prolyl Aminopeptidase 1, Soluble (XPNPEP1)

X-prolyl aminopeptidase is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-prolyl aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby complementing the pancreatic peptidases.

XPNPEPL, that encodes a 623-amino acid protein exhibiting 44% sequence identity and 62% sequence similarity to pig kidney X-prolyl aminopeptidase and high sequence homology to proteins in S. pombe and S. cerevisiae.