X-Ray Repair Cross Complementing 3 (XRCC3)

DNA repair protein XRCC3
X-Ray Repair Cross Complementing 3 (XRCC3)
XRCC3 encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. These results indicated that XRCC3 function is not limited to HR initiation, but extends to later stages in formation and resolution of HR intermediates, possibly by stabilizing heteroduplex DNA. The results further demonstrated that HR defects can promote genomic instability not only through failure to initiate HR, but also through aberrant processing of HR intermediates. The authors suggested that both mechanisms may contribute to carcinogenesis in HR-deficient cells.
Organism species: Homo sapiens (Human)
  • Protein RPG146Hu01Recombinant X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • AntibodyPAG146Hu01Polyclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • AntibodyMAG146Hu21Monoclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • Assay KitSEG146HuELISA Kit for X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • Assay KitSCG146HuCLIA Kit for X-Ray Repair Cross Complementing 3 (XRCC3)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPG146Mu01Recombinant X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • AntibodyPAG146Mu01Polyclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • AntibodyMAG146Mu21Monoclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • Assay KitSEG146MuELISA Kit for X-Ray Repair Cross Complementing 3 (XRCC3)Customize
  • Assay KitSCG146MuCLIA Kit for X-Ray Repair Cross Complementing 3 (XRCC3)Customize
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