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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
X-Ray Repair Cross Complementing 3 (XRCC3)
XRCC3 encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. These results indicated that XRCC3 function is not limited to HR initiation, but extends to later stages in formation and resolution of HR intermediates, possibly by stabilizing heteroduplex DNA. The results further demonstrated that HR defects can promote genomic instability not only through failure to initiate HR, but also through aberrant processing of HR intermediates. The authors suggested that both mechanisms may contribute to carcinogenesis in HR-deficient cells.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPG146Hu01 Recombinant X-Ray Repair Cross Complementing 3 (XRCC3) Customize
Antibodies PAG146Hu01 Polyclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Customize
MAG146Hu21 Monoclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Customize
Assay Kits SEG146Hu ELISA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) Customize
SCG146Hu CLIA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPG146Mu01 Recombinant X-Ray Repair Cross Complementing 3 (XRCC3) Customize
Antibodies PAG146Mu01 Polyclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Customize
MAG146Mu21 Monoclonal Antibody to X-Ray Repair Cross Complementing 3 (XRCC3) Customize
Assay Kits SEG146Mu ELISA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) Customize
SCG146Mu CLIA Kit for X-Ray Repair Cross Complementing 3 (XRCC3) Customize