Xeroderma Pigmentosum, Complementation Group A (XPA)

XP-A; XPAC; XP1; DNA repair protein complementing XP-A cells
Xeroderma Pigmentosum, Complementation Group A (XPA)
XPA encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. The deduced 273-amino acid protein has a calculated molecular mass of 31 kD. The human protein is 95% similar to the mouse protein and contains several alpha-helices and a zinc-finger motif, consistent with a DNA-binding protein. Two mRNAs, 1.3-1.4 kb and 1.0-1.1 kb, were detected in normal human cells. Sequence analysis identified a truncated XPA protein that could be translated from an ATG present at position 176, which retained sufficient function to partially restore the DNA repair defect in XPA cells. A 1.0-1.1-kb mouse Xpa mRNA was also identified.
Organism species: Homo sapiens (Human)
  • Protein RPE744Hu01Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • AntibodyPAE744Hu01Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • AntibodyMAE744Hu21Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • Assay KitSEE744HuELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • Assay KitSCE744HuCLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPE744Mu01Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • AntibodyPAE744Mu01Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • AntibodyMAE744Mu21Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • Assay KitSEE744MuELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • Assay KitSCE744MuCLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPE744Ra01Recombinant Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • AntibodyPAE744Ra01Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • AntibodyMAE744Ra21Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • Assay KitSEE744RaELISA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
  • Assay KitSCE744RaCLIA Kit for Xeroderma Pigmentosum, Complementation Group A (XPA)Customize
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