Yip1 Domain Family, Member 5 (YIPF5)

YIPF5 was significantly induced by TGFB1 in coronary smooth muscle cells but not in fibroblasts.The most common transcript encodes a deduced 257- amino acid protein with 4 or 5 transmembrane domains forming a characteristic Rab GTPase-interacting factor domain. Northern blot analysis detected a major 2-kb transcript expressed at highest levels in liver, heart, skeletal muscle, kidney, and small intestine with low to no expression in other tissues analyzed. Heart and skeletal muscle expressed an additional 7-kb transcript. RT-PCR analysis detected highest expression in coronary smooth muscle cells, followed by duodenum, heart, ileum, jejunum, pancreas, prostate, retina, small intestine, uterus, fibroblasts, and colon and lung tumor. SMAP5 colocalized with a cis-Golgi marker in transfected HeLa cells.