Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT)
ZC3HDC9; ZC3H9; GPATC6; GPATCH6; ZIP; G patch domain-containing protein 6; Zinc finger CCCH domain-containing protein 9; Zinc finger and G patch domain-containing protein
ZGPAT, Contains 1 C3H1-type zinc finger. Contains 1 G-patch domain. Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Six new targets of epigenetic inactivation (IRX3, WNT10A, WNT6, RARalpha, BMP7 and ZGPAT). These targets displayed cell line and tumor specific differential methylation when compared with normal brain samples, suggesting they may have utility as biomarkers.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) ELISA Kit Customized Service Offer