Fruitless (FRU)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.

By EST database analysis, followed by PCR of a human B lymphoblastoid cell line cDNA library, Herberg et al. (1998) cloned ZBTB22, which they called BING1. The deduced 634-amino acid protein contains an N-terminal POZ/BTB domain and a C-terminal C2H2-type zinc finger domain.By genomic sequence analysis, Herberg et al. (1998) mapped the ZBTB22 gene to a gene cluster on chromosome 6p21.3 that includes tapasin .