Zinc Finger And BTB Domain Containing Protein 25 (ZBTB25)

Chardin et al. (1991) isolated a human cDNA encoding a protein with 2 zinc fingers in its C-terminal part, which they named KUP for Kruppel-related protein. Genomic sequences hybridizing with the human KUP probe were found in rat and mouse. The highest levels of expression of the gene were found in testis, fetal liver, and hematopoietic cells.

The KUP protein is 433 amino acids long, has a molecular weight of about 50 kD, and binds to DNA. Its structure, resembling that of the Kruppel family, suggests that it is also a transcription factor.By in situ hybridization, Chardin et al. (1991) assigned the ZNF46 gene to chromosome 14q23-q24.