Zinc Finger And BTB Domain Containing Protein 7B (ZBTB7B)

ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes and has a role in development.

mouse Zfp67 bound specifically to a guanine-rich cis-acting element present twice in the promoter region of the mouse Col1a1 gene, and Zfp67 activated transcription from the Col1a1 promoter.ZFP67 enhanced CDCP1 transcription in the human hematopoietic cell line K562, but not in Jurkat cells. Chromatin immunoprecipitation studies showed that ZFP67 bound to the CCP1 promoter in K562 cells, but not in Jurkat cells. Demethylation of the CpG sequences in lymphocytes induced CDCP1 expression, and its expression was further increased with ZFP67 overexpression.