Zinc Finger And SCAN Domain Containing Protein 12 (ZSCAN12)

By sequencing clones obtained from a size-fractionated brain cDNA library, Ishikawa et al. (1997) cloned ZSCAN12, which they called KIAA0426. The transcript has an Alu repeat in its 3-prime UTR. The deduced 604-amino acid protein shares significant homology with mouse Zfp96. In vitro-translated ZSCAN12 had an apparent molecular mass of 81 kD by SDS-PAGE. RT-PCR detected low ZCAN12 expression in lung, thymus, prostate, testis, and ovary, with little to no expression in all other tissues examined.By radiation hybrid analysis, Ishikawa et al. (1997) mapped the ZSCAN12 gene to chromosome 6.ZSCAN12 has been referred to as ZFP96 or ZNF96 due to its homology with mouse Zfp96; however, it is distinct from the ZNF96 gene on chromosome 19 reported by Bellefroid et al. (1993).