Zinc Finger CCCH-Type Containing Protein 12D (ZC3H12D)

ZC3H12D has a predicted molecular mass of 34 kD and contains a zinc finger CCCH (C-x8-C-x5-C-x3-H) motif. The protein shares significant blocks of conservation with homologs in other mammals and in lower organisms such as zebrafish and Drosophila.

Wang et al. (2007) performed in vitro clonogenic and in vivo nude mouse studies which showed that overexpression of the ZC3H12D 106A allele exerts tumor suppressor function compared with the G allele.ZC3H12D gene was located within a region containing a lung cancer susceptibility locus, but association studies of the A/G SNP demonstrated no association between the less frequent 106G (arginine) allele and lung cancer susceptibility in the families studied by Bailey-Wilson et al. (2004).