Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20)
RBSN; Rabenosyn-5; 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5
Rabenosyn-5 colocalized with EEA1 on RAB5-positive endosomes in HeLa cells. Mutation analysis indicated that the FYVE domain of rabenosyn-5 was required for endosome targeting. Rabenosyn-5 was complexed with the Sec1-like protein VPS45 (VPS45A), and rabenosyn-5 appeared to serve as a molecular link between VPS45 and RAB5. Both EEA1 and rabenosyn-5 were required for early endosomal fusion, but only rabenosyn-5 overexpression inhibited processing of procathepsin D to its 47-kD intermediate, suggesting that the 2 proteins play distinct roles in endosomal trafficking.The deduced 784-amino acid protein contains an N-terminal C2H2-type zinc finger domain, a central FYVE finger domain, and 5 copies of the amino acid motif NPF at its C terminus.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) ELISA Kit Customized Service Offer